Sparking Fire Under the Skin? Answers From the Association of Complement Genes With Pemphigus Foliaceus

Sparking Fire Under the Skin? Answers From the Association of Complement Genes With Pemphigus Foliaceus

Skin blisters of pemphigus foliaceus (PF) present concomitant deposition of autoantibodies and components of the complement system (CS), whose gene polymorphisms are associated with susceptibility to different autoimmune diseases. To investigate these in PF, we evaluated 992 single-nucleotide polymo...

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Veröffentlicht in:Frontiers in immunology 2018-04, Vol.9, p.695-695
Hauptverfasser: Bumiller-Bini, Valéria, Cipolla, Gabriel Adelman, de Almeida, Rodrigo Coutinho, Petzl-Erler, Maria Luiza, Augusto, Danillo Gardenal, Boldt, Angelica Beate Winter
Format: Artikel
Sprache:eng
Schlagworte:
acantholysis
alternative pathway
Animals
complement
Complement System Proteins - genetics
Genotype
Humans
Immunology
lectin pathway
membrane attack complex
Pemphigus - genetics
pemphigus foliaceus
Polymorphism, Single Nucleotide
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Zusammenfassung:Skin blisters of pemphigus foliaceus (PF) present concomitant deposition of autoantibodies and components of the complement system (CS), whose gene polymorphisms are associated with susceptibility to different autoimmune diseases. To investigate these in PF, we evaluated 992 single-nucleotide polymorphisms (SNPs) of 44 CS genes, genotyped through microarray hybridization in 229 PF patients and 194 controls. After excluding SNPs with minor allele frequency
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2018.00695