Survival Outcomes of Cervical Esophageal Cancer Treated with Definitive Chemoradiotherapy using Intensity modulated or 3D Conformal Radiation Therapy: A Single Institute Experience

Abstract Objective: The aim of this study is to report the survival and treatment results of patients with cervical esophageal cancer treated with definitive chemoradiotherapy, whose incidence is very low in the population and there is not enough information about treatment and toxicity results in the literature. Material and Method: Between 2013 and 2022, 10 patients (six males and four females) with cervical esophageal cancer treated with definitive chemoradiotherapy were included. Among these patients, seven had stage II disease, one stage III, and 2 stage IVA. All patients received radiotherapy at a median dose of 50.4 Gy and concurrent weekly chemotherapy. Results: The median follow-up period was 18 months. The two-year and 5-year overall survival rates were 42.2% and 21.1%, respectively. The two-year and 5-year disease-free survival rates were 45.7% and 22.9%, respectively. Disease progression was noted in 3 out of 10 patients (30%). Three patients were still alive during analyze. Percutaneous enteral gastrostomy was performed in 3 of 10 patients. These requirement occured in 1 due to local progression, and in the remaining 2 patients due to the side effect of RT. Conclusions: Overall survival rates were low, as similar findings appear in the literature. It was remarkable that the need for a percutaneous enteral gastrostomy was not observed in the IMRT group. All patients with complete remission were in stage 2. Öz Amaç: Bu çalışmanın amacı, popülasyonda insidansı çok düşük olan ve literatürde tedavi ve toksisite sonuçları hakkında yeterli bilgi bulunmayan, definitif kemoradyoterapi ile tedavi edilen servikal özofagus kanserli hastaların sağkalım ve tedavi sonuçlarını bildirmektir. Gereç ve Yöntem: 2013-2022 yılları arasında definitif kemoradyoterapi ile tedavi edilen servikal özofagus kanserli 10 hasta (altı erkek ve dört kadın) dahil edildi. Bu hastaların yedisinde evre II hastalık, birinde evre III ve ikisinde evre IVA hastalık vardı. Tüm hastalar medyan 50.4 Gy dozda radyoterapi ve eş zamanlı haftalık kemoterapi aldı. Bulgular: Ortanca takip süresi 18 aydı. İki yıllık ve 5 yıllık genel sağkalım oranları sırasıyla %42.2 ve %21.1 idi. İki yıllık ve 5 yıllık hastalıksız sağkalım oranları sırasıyla %45.7 ve %22.9 idi. 10 hastanın 3'ünde (%30) hastalık progresyonu kaydedildi. Analiz sırasında üç hasta hala hayattaydı. 10 hastanın 3'üne perkütan enteral gastrostomi uygulandı. Bu gereksinim 1 hastada lokal progresyon nedeniyle, geri kalan 2 hastada RT'n