The impact of drug resistance on the risk of tuberculosis infection and disease in child household contacts: a cross sectional study

The relative fitness of organisms causing drug-susceptible (DS) and multidrug-resistant (MDR) tuberculosis (TB) is unclear. We compared the risk of TB infection and TB disease in young child household contacts of adults with confirmed DS-TB and MDR-TB. In this cross-sectional analysis we included da...

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Veröffentlicht in:	BMC infectious diseases 2017-08, Vol.17 (1), p.593-593, Article 593
Hauptverfasser:	Golla, Vera, Snow, Kathryn, Mandalakas, Anna M, Schaaf, H Simon, Du Preez, Karen, Hesseling, Anneke C, Seddon, James A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adults Bacteriology Causes of Child, Preschool Children Children & youth Cohort Studies Complications and side effects Confidence intervals Cross-Sectional Studies Data processing Demographic aspects Diagnosis Disease Disease Transmission, Infectious Drug resistance Drug resistance in microorganisms Drug Resistance, Multiple, Bacterial Exposure Family Characteristics Female Fitness Health risks HIV Households Human immunodeficiency virus Humans Impact resistance Infant Infection Infections Infectious diseases Laboratories Male Meta-analysis Multidrug resistance Multidrug resistant organisms Mutation Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - pathogenicity Odds Ratio Organisms Regression analysis Reproductive fitness Resistance Risk Risk Factors Skin diseases Skin tests South Africa Studies Tuberculin Tuberculin Test Tuberculosis Tuberculosis - drug therapy Tuberculosis - transmission Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - transmission Virulence
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Zusammenfassung:	The relative fitness of organisms causing drug-susceptible (DS) and multidrug-resistant (MDR) tuberculosis (TB) is unclear. We compared the risk of TB infection and TB disease in young child household contacts of adults with confirmed DS-TB and MDR-TB. In this cross-sectional analysis we included data from two community-based contact cohort investigation studies conducted in parallel in Cape Town, South Africa. Children
ISSN:	1471-2334 1471-2334
DOI:	10.1186/s12879-017-2668-2