Role of Bcl-3 in solid tumors

Bcl-3 is an established oncogene in hematologic malignancies, such as B-cell chronic lymphocytic leukemias. Nevertheless, recent research has shown that it also participates in progression of diverse solid tumors. The present review summarizes the current knowledge of Bcl3 role in solid tumors progr...

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Veröffentlicht in:	Molecular cancer 2011-12, Vol.10 (1), p.152-152
Hauptverfasser:	Maldonado, Vilma, Melendez-Zajgla, Jorge
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis B-Lymphocytes - pathology Binding sites Cell cycle Cell Proliferation Deregulation DNA damage Genes Humans Insulin Kinases Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Leukemia, Lymphocytic, Chronic, B-Cell - pathology Lymphoma Phosphorylation Proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Review Signal transduction Skin Transcription Factors - genetics Transcription Factors - metabolism Tumors
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Beschreibung
Zusammenfassung:	Bcl-3 is an established oncogene in hematologic malignancies, such as B-cell chronic lymphocytic leukemias. Nevertheless, recent research has shown that it also participates in progression of diverse solid tumors. The present review summarizes the current knowledge of Bcl3 role in solid tumors progression, including some new insights in its possible molecular mechanisms of action.
ISSN:	1476-4598 1476-4598
DOI:	10.1186/1476-4598-10-152