Anti-osteoporosis properties of phosphorylated collagen peptide-magnesium chelates in osteoblast MC3T3-E1 cells and ovariectomized mice

The anti-osteoporosis properties of PCP-Mg were investigated by exploring the osteogenic function of osteoblasts, the preventive effect of ovariectomy (OVX)-induced bone loss in mice, and the potential mechanism underlying the effects on osteoporosis prevention. [7] Magnesium ions have been proved to promote the proliferation and differentiation of osteoblasts,[8] and magnesium chelation can promote the protective effect of peptides on cells against oxidative stress,[9] which may be conducive to the maintenance of anti-osteoporosis activity under pathological conditions. [...]PCP-Mg exhibited the multiple effects in the therapeutic effect on estrogen deficiency osteoporosis through the inhibition of oxidative stress and inflammation and the upregulated expression of osteogenic-related genes to promote the maintenance of bone homeostasis in estrogen-deficient mice. Yaqin Huang, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China E-Mail: huangyq@mail.buct.edu.cn; Yuepeng Guan, Beijing Key Laboratory of Clothing Materials R&D and Assessment, Beijing Engineering Research Center of Textile Nano Fiber, Beijing Institute of Fashion Technology, Beijing 100029, China E-Mail: 20210007@bift.edu.cn; Tengfei Yu, Department of Ultrasound, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100160, ChinaE-Mail: