Adrenomedullin 2 increases cardiac sympathetic nerve activity in parallel to heart rate in normal conscious sheep

Adrenomedullin 2 increases cardiac sympathetic nerve activity in parallel to heart rate in normal conscious sheep

Both adrenomedullin 2 (AM2) and sympathetic nerve activity (SNA) have been shown to be involved in regulating cardiovascular activity, but whether any interaction between these two systems exists remains to be determined. In this study, we examine the effects of intravenous AM2 infusions on SNA dire...

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Veröffentlicht in:Physiological reports 2019-05, Vol.7 (10), p.e14096-n/a
Hauptverfasser: Charles, Christopher J., Jardine, David L., Rademaker, Miriam T., Mark Richards, A.
Format: Artikel
Sprache:eng
Schlagworte:
Adrenomedullin
Arterial pressure
Biological activity
Blood pressure
cardiac output
Central nervous system
Consciousness
Electrodes
Epinephrine
Heart rate
Homeostasis
Intravenous administration
Norepinephrine
Original Research
Ostomy
Peptides
Physiology
Plasma
Pulmonary arteries
Sheep
Studies
Sympathetic nerves
sympathetic nervous system
Veins & arteries
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Zusammenfassung:Both adrenomedullin 2 (AM2) and sympathetic nerve activity (SNA) have been shown to be involved in regulating cardiovascular activity, but whether any interaction between these two systems exists remains to be determined. In this study, we examine the effects of intravenous AM2 infusions on SNA directed toward the heart (cardiac SNA (CSNA)) in healthy sheep studied in the conscious state. In response to AM2, arterial pressure was reduced (P = 0.005) with both heart rate (P 
ISSN:2051-817X
DOI:10.14814/phy2.14096