A Prospective Observational Study of Antibiotic Therapy in Febrile Neutropenia Patients with Hematological Malignances from Multiple centers in Northeast China

Highlights • FN Patients with respiratory infection had worse outcomes from antibiotic treatment. • Monotherapy with empirical drugs was effective as the optimal initial choice. • The period of neutropenia after fever over 9 days was a predictor of unfavorable outcome. • Early recovery of ANC counts also indicates better outcome. • The patients with multi-bacterial infection had poor antibiotic treatment outcome. • Standard operation could reduce catheter-related infection.