Dose response for Salmonella Typhimurium and Enteritidis and other nontyphoid enteric salmonellae

This dose response assessment combines data from 6 human challenge studies and 44 outbreaks to determine infectivity and pathogenicity of several serotypes of nontyphoid Salmonella. Outcomes focus on the major serotypes Salmonella Enteritidis and Typhimurium, showing that Typhimurium is less infectious and has a lower probability of causing acute illness in infected subjects. The dose response relation of Salmonella Enteritidis is less steep than that of Typhimurium, indicating greater heterogeneity in infectivity and pathogenicity. This study revisits an older study with less flexible methods that could not combine the widely different outcomes of challenge studies and outbreaks, and had limited capability for dealing with missing information. Reported outcomes are in a format that allows use in calculations of uncertainty for quantitative risk assessment. •Salmonella Enteritidis and Typhimurium are common foodborne pathogens.•Infectivity of pathogens can be estimated challenge studies and qualifying outbreaks.•This study combines data from both sources into a multilevel dose response model.•Salmonella Enteritidis is more infectious and more pathogenic than Typhimurium•Salmonella Typhimurium shows less variation in pathogenicity.