Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study

Recently, loss-of-function variants in TLR7 were identified in two families in which COVID-19 segregates like an X-linked recessive disorder environmentally conditioned by SARS-CoV-2. We investigated whether the two families represent the tip of the iceberg of a subset of COVID-19 male patients. Thi...

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Veröffentlicht in:	eLife 2021-03, Vol.10
Hauptverfasser:	Fallerini, Chiara, Daga, Sergio, Mantovani, Stefania, Benetti, Elisa, Picchiotti, Nicola, Francisci, Daniela, Paciosi, Francesco, Schiaroli, Elisabetta, Baldassarri, Margherita, Fava, Francesca, Palmieri, Maria, Ludovisi, Serena, Castelli, Francesco, Quiros-Roldan, Eugenia, Vaghi, Massimo, Rusconi, Stefano, Siano, Matteo, Bandini, Maria, Spiga, Ottavia, Capitani, Katia, Furini, Simone, Mari, Francesca, Renieri, Alessandra, Mondelli, Mario U, Frullanti, Elisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Case-Control Studies Cell culture Comparative analysis Coronaviruses COVID-19 COVID-19 - diagnosis COVID-19 - epidemiology COVID-19 - genetics Cytokines Disease susceptibility Gene expression Genes Genetic Predisposition to Disease Genetics and Genomics Health aspects HEK293 Cells Hereditary diseases Humans Interferon Italy - epidemiology LASSO Logistic Regression Analysis Male Males Medical research Medicine Medicine, Experimental Middle Aged Pathogens Patients Phenotypes Polymorphism, Single Nucleotide Proteins SARS-CoV-2 - isolation & purification Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Short Report TLR7 TLR7 protein Toll-Like Receptor 7 - genetics Toll-like receptors Viruses
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Zusammenfassung:	Recently, loss-of-function variants in TLR7 were identified in two families in which COVID-19 segregates like an X-linked recessive disorder environmentally conditioned by SARS-CoV-2. We investigated whether the two families represent the tip of the iceberg of a subset of COVID-19 male patients. This is a nested case-control study in which we compared male participants with extreme phenotype selected from the Italian GEN-COVID cohort of SARS-CoV-2-infected participants (
ISSN:	2050-084X 2050-084X
DOI:	10.7554/eLife.67569