No genetic causal association between Alzheimer's disease and osteoporosis: A bidirectional two-sample Mendelian randomization study

No genetic causal association between Alzheimer's disease and osteoporosis: A bidirectional two-sample Mendelian randomization study

Many observational studies have found an association between Alzheimer's disease (AD) and osteoporosis. However, it is unclear whether there is causal genetic between osteoporosis and AD. A two-sample Mendelian randomization (MR) study was used to investigate whether there is a causal relations...

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Veröffentlicht in:Frontiers in aging neuroscience 2023-01, Vol.15, p.1090223-1090223
Hauptverfasser: Hu, Hongxin, Mei, Jian, Cai, Yuanqing, Ding, Haiqi, Niu, Susheng, Zhang, Wenming, Fang, Xinyu
Format: Artikel
Sprache:eng
Schlagworte:
Aging Neuroscience
Alzheimer's disease
Bone density
bone mineral density
Cardiovascular disease
causal relationship
Confidence intervals
Fractures
Genomes
Kinases
Mendelian randomization
Neurodegenerative diseases
Observational studies
Osteoporosis
Pleiotropy
Proteins
Sensitivity analysis
Single-nucleotide polymorphism
Statistical analysis
Variables
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Zusammenfassung:Many observational studies have found an association between Alzheimer's disease (AD) and osteoporosis. However, it is unclear whether there is causal genetic between osteoporosis and AD. A two-sample Mendelian randomization (MR) study was used to investigate whether there is a causal relationship between osteoporosis and AD. Genes for osteoporosis and AD were obtained from published the genome-wide association studies (GWAS). Single nucleotide polymorphisms (SNPs) with significant genome-wide differences (  
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2023.1090223