Gamma heavy chain disease: a retrospective analysis of 6 cases

According to the WHO 2016 classification, heavy chain disease is a mature B lymphocytic neoplasm and can be categorized as α, γ, and µ heavy chain disease according to the heavy chain antigen. [...]the amount of heavy chain M protein in the serum and urine of patients is often low, and only three of the six patients in this cohort had positive serum protein electrophoresis. [...]immunofixation electrophoresis, which is more sensitive, is required for diagnosis. Some new detection techniques, such as capillary electrophoresis and heavy and light chain assays, can improve the sensitivity of heavy chain detection [4]. [...]gamma heavy chain disease was clinically heterogeneous and often combined with autoimmune diseases and lymphoproliferative neoplasms, which should be carefully screened at diagnosis and followed up for aggressive lymphoma transformation by clinicians. Gamma Heavy Chain Disease with T-cell large granular lymphocytic leukemia: a Case Report and Review of the Literature[J].