Diagnostic interaction between bovine tuberculosis (bTB) and Johne's disease in bTB highly prevalent dairy farms of Uruguay

•In Uruguay (Uy), bTB highly prevalent dairy herds have emerged.•Johne's disease (JD) control programs lack at the national level in Uy.•In high prevalence coinfected herds, bTB- and JD-diagnosis interact.•An integrated control program is needed for high prevalent coinfected dairies in Uy. The consolidation of the dairy industry, with increase in sizes, density and productivity of the herds, was associated to unprecedented bovine tuberculosis (bTB) prevalence levels in dairy herds in Uruguay, where Johne's disease (JD), another mycobacterial disease, is also prevalent. Here, we aimed to characterize the association between bTB- and JD-diagnostic results in two heavily bTB- and JD-coinfected dairy herds. Results from bTB-intradermal tests and JD-ELISA in 686 cows indicated a significantly (P