Anti-Depressant Properties of Crocin Molecules in Saffron
Saffron is a valued herb, obtained from the stigmas of the Linn (Iridaceae), with therapeutic effects. It has been described in pharmacopoeias to be variously acting, including as an anti-depressant, anti-carcinogen, and stimulant agent. The therapeutic effects of saffron are harbored in its bioacti...
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Veröffentlicht in: | Molecules (Basel, Switzerland) Switzerland), 2022-03, Vol.27 (7), p.2076 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Saffron is a valued herb, obtained from the stigmas of the
Linn (Iridaceae), with therapeutic effects. It has been described in pharmacopoeias to be variously acting, including as an anti-depressant, anti-carcinogen, and stimulant agent. The therapeutic effects of saffron are harbored in its bioactive molecules, notably crocins, the subject of this paper. Crocins have been demonstrated to act as a monoamine oxidase type A and B inhibitor. Furthermore, saffron petal extracts have experimentally been shown to impact contractile response in electrical field stimulation. Other research suggests that saffron also inhibits the reuptake of monoamines, exhibits
-methyl-d-aspartate antagonism, and improves brain-derived neurotrophic factor signaling. A host of experimental studies found saffron/crocin to be similarly effective as fluoxetine and imipramine in the treatment of depression disorders. Saffron and crocins propose a natural solution to combat depressive disorders. However, some hurdles, such as stability and delivery, need to be overcome. |
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ISSN: | 1420-3049 1420-3049 |
DOI: | 10.3390/molecules27072076 |