Synthesis and Evaluation of Some Uracil Nucleosides as Promising Anti-Herpes Simplex Virus 1 Agents

Since herpes simplex virus type 1 (HSV-1) infection is so widespread, several antiviral drugs have been developed to treat it, among which are uracil nucleosides. However, there are major problems with the current medications such as severe side-effects and drug resistance. Here we present some newl...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2021-05, Vol.26 (10), p.2988
Hauptverfasser:	Awad, Samir Mohamed, Ali, Shima Mahmoud, Mansour, Yara Essam, Fatahala, Samar Said
Format:	Artikel
Sprache:	eng
Schlagworte:	acyclic nucleosides Acyclovir Acyclovir - pharmacology Animals antiviral activities Antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Chlorocebus aethiops Clinical trials COVID-19 cyclic nucleosides Cytopathogenic Effect, Viral - drug effects DNA polymerase Drug resistance Drugs FDA approval Herpes simplex Herpes viruses Herpesvirus 1, Human - drug effects Infections Nucleosides Phosphorylation Prevention Reference Standards RNA polymerase Severe acute respiratory syndrome coronavirus 2 Side effects Structure-Activity Relationship Sugar Uracil Uridine - chemical synthesis Uridine - chemistry Uridine - pharmacology Vero Cells Viral infections Viruses
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Zusammenfassung:	Since herpes simplex virus type 1 (HSV-1) infection is so widespread, several antiviral drugs have been developed to treat it, among which are uracil nucleosides. However, there are major problems with the current medications such as severe side-effects and drug resistance. Here we present some newly synthesized cyclic and acyclic uracil nucleosides that showed very promising activity against HSV-1 compared to acyclovir.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules26102988