Regioselectivity in the multicomponent reaction of 5-aminopyrazoles, cyclic 1,3-diketones and dimethylformamide dimethylacetal under controlled microwave heating

Regioselectivity in the multicomponent reaction of 5-aminopyrazoles, cyclic 1,3-diketones and dimethylformamide dimethylacetal under controlled microwave heating

The multicomponent reaction of 5-aminopyrazole derivatives with cyclic 1,3-dicarbonyl compounds and dimethylformamide dimethylacetal (DMFDMA) in DMF at 150 °C under controlled microwave heating afforded regioselectively 8,9-dihydropyrazolo[1,5-a]quinazolin-6(7H)-ones 6 rather than the corresponding...

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Veröffentlicht in:Beilstein journal of organic chemistry 2012-01, Vol.8 (1), p.18-24
Hauptverfasser: Sadek, Kamal Usef, Mekheimer, Ramadan Ahmed, Mohamed, Tahany Mahmoud, Moustafa, Moustafa Sherief, Elnagdi, Mohamed Hilmy
Format: Artikel
Sprache:eng
Schlagworte:
aminopyrazoles
Chemistry
dimedone
DMFDMA
Full Research Paper
regioselectivity
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Zusammenfassung:The multicomponent reaction of 5-aminopyrazole derivatives with cyclic 1,3-dicarbonyl compounds and dimethylformamide dimethylacetal (DMFDMA) in DMF at 150 °C under controlled microwave heating afforded regioselectively 8,9-dihydropyrazolo[1,5-a]quinazolin-6(7H)-ones 6 rather than the corresponding dihydropyrazolo[5,1-b]quinazolin-8(5H)-ones 4.
ISSN:1860-5397
1860-5397
DOI:10.3762/bjoc.8.3