Intestinal barrier disruption with Plasmodium falciparum infection in pregnancy and risk of preterm birth: a cohort studyResearch in context

Intestinal barrier disruption with Plasmodium falciparum infection in pregnancy and risk of preterm birth: a cohort studyResearch in context

Background: Malaria in early pregnancy is a risk factor for preterm birth and is associated with sustained inflammation and dysregulated angiogenesis across gestation. This study investigated whether malaria is associated with increased gut leak and whether this contributes to systemic inflammation,...

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Veröffentlicht in:EBioMedicine 2023-11, Vol.97, p.104808
Hauptverfasser: Julie K. Wright, Andrea M. Weckman, Michelle Ngai, Veselina Stefanova, Kathleen Zhong, Chloe R. McDonald, Robyn E. Elphinstone, Andrea L. Conroy, Bryan A. Coburn, Mwayi Madanitsa, Steve M. Taylor, Feiko O. ter Kuile, Kevin C. Kain
Format: Artikel
Sprache:eng
Schlagworte:
Gut leak
Intestinal barrier disruption
LBP
Malaria in pregnancy
Preterm birth
sCD14
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Zusammenfassung:Background: Malaria in early pregnancy is a risk factor for preterm birth and is associated with sustained inflammation and dysregulated angiogenesis across gestation. This study investigated whether malaria is associated with increased gut leak and whether this contributes to systemic inflammation, altered angiogenesis, and preterm birth. Methods: We quantified plasma concentrations of gut leak markers, soluble CD14 (sCD14) and lipopolysaccharide binding protein (LBP) from 1339 HIV-negative pregnant Malawians at
ISSN:2352-3964