Preparation and Chiral HPLC Separation of the Enantiomeric Forms of Natural Prostaglandins

Preparation and Chiral HPLC Separation of the Enantiomeric Forms of Natural Prostaglandins

Four enantiomeric forms of natural prostaglandins, ent-PGF2α ((−)-1), ent-PGE2 ((+)-2) ent-PGF1α ((−)-3), and ent-PGE1 ((+)-4) have been synthetized in gram scale by Corey synthesis used in the prostaglandin plants of CHINOIN, Budapest. Chiral HPLC methods have been developed to separate the enantio...

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Veröffentlicht in:Chemistry an international journal 2020-09, Vol.2 (3), p.727-741
Hauptverfasser: Enesei, Márton, Takács, László, Tormási, Enikő, Tóthné Rácz, Adrienn, Róka, Zita, Kádár, Mihály, Kardos, Zsuzsanna
Format: Artikel
Sprache:eng
Schlagworte:
chiral HPLC
ent-PGE1
ent-PGE2
ent-PGF1α
ent-PGF2α
preparation
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Zusammenfassung:Four enantiomeric forms of natural prostaglandins, ent-PGF2α ((−)-1), ent-PGE2 ((+)-2) ent-PGF1α ((−)-3), and ent-PGE1 ((+)-4) have been synthetized in gram scale by Corey synthesis used in the prostaglandin plants of CHINOIN, Budapest. Chiral HPLC methods have been developed to separate the enantiomeric pairs. Enantiomers of natural prostaglandins can be used as analytical standards to verify the enantiopurity of synthetic prostaglandins, or as biomarkers to study oxidation processes in vivo.
ISSN:2624-8549
2624-8549
DOI:10.3390/chemistry2030047