Sixteen New Prenylated Flavonoids from the Fruit of Sinopodophyllum hexandrum

Sixteen New Prenylated Flavonoids from the Fruit of Sinopodophyllum hexandrum

Sixteen new prenylated flavonoids, sinoflavonoids P-Z ( - ) and sinoflavonoids NA-NE ( - ), were isolated from the fruit of , along with eight known analogues ( - ). Their structures were elucidated on the basis of extensive spectroscopic data (HR-ESI-MS, H-NMR, C-NMR, HSQC, HMBC). The cytotoxic act...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2019-09, Vol.24 (17), p.3196
Hauptverfasser: Sun, Yanjun, Chen, Haojie, Wang, Junmin, Gao, Meiling, Zhao, Chen, Han, Ruijie, Chen, Hui, Li, Meng, Xue, Guimin, Feng, Weisheng
Format: Artikel
Sprache:eng
Schlagworte:
Berberidaceae - chemistry
Cell Survival - drug effects
Correlation
cytotoxic activity
Flavonoids
Flavonoids - chemistry
Flavonoids - pharmacology
Fruit - chemistry
Hep G2 Cells
Humans
Hydrocarbons
Hydroxyl groups
Inhibitory Concentration 50
MCF-7 Cells
Methylene
Phenolic compounds
Phenols
Powder
prenylated flavonoid
Sinopodophyllum hexandrum
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Zusammenfassung:Sixteen new prenylated flavonoids, sinoflavonoids P-Z ( - ) and sinoflavonoids NA-NE ( - ), were isolated from the fruit of , along with eight known analogues ( - ). Their structures were elucidated on the basis of extensive spectroscopic data (HR-ESI-MS, H-NMR, C-NMR, HSQC, HMBC). The cytotoxic activities of compounds - , , and were evaluated by MTT assay. Compound showed the most potent cytotoxicity in MCF-7, and HepG2 cell lines, with IC values of 6.25 and 3.83 μM, respectively.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24173196