Association of apolipoprotein M and sphingosine-1-phosphate with brown adipose tissue after cold exposure in humans

The HDL-associated apolipoprotein M (apoM) and its ligand sphingosine-1-phosphate (S1P) may control energy metabolism. ApoM deficiency in mice is associated with increased vascular permeability, brown adipose tissue (BAT) mass and activity, and protection against obesity. In the current study, we ex...

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Veröffentlicht in:	Scientific reports 2022-11, Vol.12 (1), p.18753-18753, Article 18753
Hauptverfasser:	Borup, Anna, Donkin, Ida, Boon, Mariëtte R., Frydland, Martin, Martinez-Tellez, Borja, Loft, Annika, Keller, Sune H., Kjaer, Andreas, Kjaergaard, Jesper, Hassager, Christian, Barrès, Romain, Rensen, Patrick C. N., Christoffersen, Christina
Format:	Artikel
Sprache:	eng
Schlagworte:	692/163 692/53 Adipose tissue Adipose tissue (brown) Adipose Tissue, Brown - metabolism Animals Apolipoproteins Apolipoproteins M - metabolism Body fat Cooling Energy metabolism High density lipoprotein Humanities and Social Sciences Humans Life Sciences Lipid metabolism Lysophospholipids - metabolism Metabolism multidisciplinary Permeability Plasma Plasma levels Positron emission tomography Positron Emission Tomography Computed Tomography Science Science (multidisciplinary) Sphingosine - metabolism Sphingosine 1-phosphate
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Zusammenfassung:	The HDL-associated apolipoprotein M (apoM) and its ligand sphingosine-1-phosphate (S1P) may control energy metabolism. ApoM deficiency in mice is associated with increased vascular permeability, brown adipose tissue (BAT) mass and activity, and protection against obesity. In the current study, we explored the connection between plasma apoM/S1P levels and parameters of BAT as measured via 18 F-FDG PET/CT after cold exposure in humans. Fixed (n = 15) vs personalized (n = 20) short-term cooling protocols decreased and increased apoM (− 8.4%, P = 0.032 vs 15.7%, P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-022-21938-2