Role of Vitamin E in Ischaemic Skin Flap Survival in Rats

The efficacy of free radical scavenger – Vitamin E (VE) in salvage of ischaemic skin flaps was studied in an experimental rat skin flap model. The animals were divided into two groups – a control group (N=15) who did of receive VE and a test group (N=15) who received VE starting one week preoperativ...

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Veröffentlicht in:Indian journal of plastic surgery 1995-04, Vol.28 (2), p.80-83
Hauptverfasser: Khazanchi, Rakesh K, Pal, Sujoy, Mital, Deepak, Gupta, Kalpana, Guleria, Sandeep, Nanda, Vipul
Format: Artikel
Sprache:eng
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Zusammenfassung:The efficacy of free radical scavenger – Vitamin E (VE) in salvage of ischaemic skin flaps was studied in an experimental rat skin flap model. The animals were divided into two groups – a control group (N=15) who did of receive VE and a test group (N=15) who received VE starting one week preoperatively. No significant difference was found in flap necrosis between the control group (38.365% ± 1.398% SEM) and the test group (35.288% ± 0.635% SEM), which received therapeutic dose of VE (100 mg/kg/day. 1 mg = 1.49 I.U). Further research is needed to establish the role of vitamin E as an agent of ischaemic skin flap salvage.
ISSN:0970-0358
1998-376X
DOI:10.1055/s-0043-1775701