Short-term Effects of Opportunistic Salpingectomy on Ovarian Reserve: a Meta-analysis of Randomized Controlled Trials Based on GRADE Evidence Grading System

Background Opportunistic salpingectomy (OS) can be used as a primary prevention of ovarian cancer (OC) , but OS may cause impairment of ovarian function due to the homologous blood supply system shared by ovaries and fallopian tubes, thereby increasing the risk of ovarian aging and early menopause. Objective To evaluate the short-term effects of OS on ovarian reserve based on GRADE evidence grading system. Methods In September 2022, CNKI, Wanfang, VIP, PubMed, Web of Science, and Scopus were searched for literature assessing the short-term effects of OS on ovarian reserve from inception to 10 September 2022. Two investigators independently screened the literature and extracted the data. The Jadad scale was used to evaluate the quality of literature, Stata 17.0 software was used for data processing and meta-analysis, and GRADEpro 3.2 software was used to assess the evidence quality for the results of meta-analysis. Results A total of 9 randomized controlled trials (RCT) were included, involving 482 patients, i