Expression of β1,3-N-acetylglucosaminyltransferase-3 in Non-small Cell Lung Cancer and Its Clinical Significance

Expression of β1,3-N-acetylglucosaminyltransferase-3 in Non-small Cell Lung Cancer and Its Clinical Significance

Objective To investigate the expression of β1,3-N-acetylglucosaminyltransferase-3 gene (B3GNT3) in non-small cell lung cancer (NSCLC) tissues and its clinical significance. Methods The expression of B3GNT3 gene was analyzed by online TCGA database. The expressions of B3GNT3 protein in NSCLC tissues...

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Veröffentlicht in:Zhongliu fangzhi yanjiu 2018-08, Vol.45 (8), p.571-575
Hauptverfasser: Li, Binfeng, Xiang, Zhengkai, Xiong, Fei, Wang, Huabin, Yan, Baoguo
Format: Artikel
Sprache:chi
Schlagworte:
b3gnt3
Cancer
Clinical significance
Gene expression
Lung cancer
Medical prognosis
N-Acetylglucosinyldiphosphodolichol N-acetylglucosaminyltransferase
non-small cell lung cancer
Non-small cell lung carcinoma
Patients
prognosis
Proteins
Smoking
Tissues
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Zusammenfassung:Objective To investigate the expression of β1,3-N-acetylglucosaminyltransferase-3 gene (B3GNT3) in non-small cell lung cancer (NSCLC) tissues and its clinical significance. Methods The expression of B3GNT3 gene was analyzed by online TCGA database. The expressions of B3GNT3 protein in NSCLC tissues (n=60) and normal lung tissues (n=22) were detected by Western blot and immunohistochemical method. The relationship between the expression of B3GNT3 protein and the clinicopathological features of NSCLC patients was analyzed. Results The B3GNT3 expression in NSCLC tissues was significantly higher than that in normal lung tissues (P0.05). The overall survival time of NSCLC patients with high expression of B3GNT3 protein was shorter than that with low expression of B3GNT3 protein (P
ISSN:1000-8578
1000-8578
DOI:10.3971/j.issn.1000-8578.2018.17.1638