Chronic hepatitis B in pregnant women: is hepatitis B surface antigen quantification useful for viral load prediction?

Highlights • Perinatal transmission of hepatitis B virus (HBV) still occurs despite infant hepatitis B vaccination. • Maternal HBV viraemia is the main risk factor for perinatal transmission. • The hepatitis B surface antigen (HBsAg) level is a good viral load predictor in hepatitis B e antigen (HBe...

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Veröffentlicht in:	International journal of infectious diseases 2015-12, Vol.41 (C), p.83-89
Hauptverfasser:	Fujiko, Masita, Chalid, Maisuri T, Turyadi, Ie, Susan I, Maghfira, Syafri, Wahyuni, Ridha, Roni, Martono, Patellongi, Ilhamjaya, Massi, M. Nasrum, Muljono, David H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Base Sequence DNA, Viral - genetics Female Genotype HBsAg level HBV DNA level HBV vertical transmission Hepatitis B Antibodies - immunology Hepatitis B e Antigens - genetics Hepatitis B Surface Antigens - blood Hepatitis B virus - genetics Hepatitis B, Chronic - blood Hepatitis B, Chronic - epidemiology Hepatitis B, Chronic - virology Humans Indonesia - epidemiology Infectious Disease Infectious Disease Transmission, Vertical Mother-to-child-transmission Mutation Pregnancy Pregnancy Complications, Infectious - virology Pregnant women Prevalence Promoter Regions, Genetic Pulmonary/Respiratory Real-Time Polymerase Chain Reaction Serologic Tests Viral Load Viremia - immunology Young Adult
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Beschreibung
Zusammenfassung:	Highlights • Perinatal transmission of hepatitis B virus (HBV) still occurs despite infant hepatitis B vaccination. • Maternal HBV viraemia is the main risk factor for perinatal transmission. • The hepatitis B surface antigen (HBsAg) level is a good viral load predictor in hepatitis B e antigen (HBeAg)-positive pregnant women. • HBeAg-negative status could be due to HBV variants defective for HBeAg production. • HBV DNA quantification is not required for pregnant women with low HBsAg levels.
ISSN:	1201-9712 1878-3511
DOI:	10.1016/j.ijid.2015.11.002