General Method for the Preparation of Substituted 2-Amino-4H,5H-pyrano[4,3-b]pyran-5-ones and 2-Amino-4H-pyrano[3,2-c]pyridine-5-ones

General Method for the Preparation of Substituted 2-Amino-4H,5H-pyrano[4,3-b]pyran-5-ones and 2-Amino-4H-pyrano[3,2-c]pyridine-5-ones

Reaction of 4-hydroxy-6-methyl-2-pyrone (1a) as well as 4-hydroxy-6-methyl-2(1H)-pyridones (1b-d) with arylmethylene malononitriles or arylmethylene methyl cyanoacetates (2a-h) leads to the formation of the very stable 5,6-fused bicyclic 2-amino-4Hpyran derivatives 3a-3af.

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Bibliographische Detailangaben
Veröffentlicht in:MolBank 2000-01, Vol.5 (1), p.19-32
Hauptverfasser: Stoyanov, Edmont V, Ivanov, Ivo C, Heber, Dieter
Format: Artikel
Sprache:eng
Schlagworte:
2-c]pyridine
3-b]pyran
arylmethylene cyanoacetate
arylmethylene malononitrile
Michael addition
pyrano
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Zusammenfassung:Reaction of 4-hydroxy-6-methyl-2-pyrone (1a) as well as 4-hydroxy-6-methyl-2(1H)-pyridones (1b-d) with arylmethylene malononitriles or arylmethylene methyl cyanoacetates (2a-h) leads to the formation of the very stable 5,6-fused bicyclic 2-amino-4Hpyran derivatives 3a-3af.
ISSN:1420-3049
1420-3049
1422-8599
DOI:10.3390/50100019