Effect of antenatal magnesium sulphate on MRI biomarkers of white matter development at term equivalent age: The magnum study

Magnesium sulphate given to women immediately prior to very preterm birth protects the perinatal brain, so fewer babies die or develop cerebral palsy. How magnesium sulphate exerts these beneficial effects remains uncertain. The aim of the MagNUM Study was to assess the effect of exposure to antenat...

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Veröffentlicht in:	EBioMedicine 2020-09, Vol.59, p.102957-102957
Hauptverfasser:	Poppe, Tanya, Thompson, Benjamin, Boardman, James P, Bastin, Mark E, Alsweiler, Jane, Deib, Gerard, Harding, Jane E, Crowther, Caroline A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomarkers Female Gestational Age Humans Infant, Newborn Magnesium Sulfate - metabolism Magnesium Sulfate - pharmacology Magnetic Resonance Imaging Male Pregnancy Prenatal Diagnosis Research paper White Matter - diagnostic imaging White Matter - drug effects White Matter - metabolism
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Zusammenfassung:	Magnesium sulphate given to women immediately prior to very preterm birth protects the perinatal brain, so fewer babies die or develop cerebral palsy. How magnesium sulphate exerts these beneficial effects remains uncertain. The aim of the MagNUM Study was to assess the effect of exposure to antenatal magnesium sulphate on MRI measures of brain white matter microstructure at term equivalent age. Nested cohort study within the randomised Magnesium sulphate at 30 to
ISSN:	2352-3964 2352-3964
DOI:	10.1016/j.ebiom.2020.102957