What does the concept of the stem cell niche really mean today?

The microenvironment that metastatic cells engage and take advantage of to form a niche is a significant contributor to metastatic outgrowth. [...] the niche may possibly also contribute to cancer stem cell resistance to therapeutic intervention.

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Bibliographische Detailangaben
Veröffentlicht in:	BMC biology 2012-03, Vol.10 (1), p.19-19, Article 19
Hauptverfasser:	Lander, Arthur D, Kimble, Judith, Clevers, Hans, Fuchs, Elaine, Montarras, Didier, Buckingham, Margaret, Calof, Anne L, Trumpp, Andreas, Oskarsson, Thordur
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology Caenorhabditis elegans Caenorhabditis elegans - growth & development Caenorhabditis elegans - physiology Cancer Cell Differentiation Cell Proliferation Forum Germ Cells - cytology Grants Humans Life Sciences Mice - growth & development Mice - physiology Nematodes Neurosciences Physiological aspects Proteins Stem Cell Niche Stem cells Studies Transforming growth factors
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Beschreibung
Zusammenfassung:	The microenvironment that metastatic cells engage and take advantage of to form a niche is a significant contributor to metastatic outgrowth. [...] the niche may possibly also contribute to cancer stem cell resistance to therapeutic intervention.
ISSN:	1741-7007 1741-7007
DOI:	10.1186/1741-7007-10-19