Effects of controlled and pressure support mechanical ventilation on rat diaphragm muscle Efeitos da ventilação mecânica controlada e por pressão de suporte no músculo diafragma de ratos

Effects of controlled and pressure support mechanical ventilation on rat diaphragm muscle Efeitos da ventilação mecânica controlada e por pressão de suporte no músculo diafragma de ratos

PURPOSE: The objective of this study was to analyze the effects of Pressure Controlled Ventilation mode (PCV-C) and PSV mode in diaphragm muscle of rats. METHODS: Wistar rats (n=18) were randomly assigned to the control group or to receive 6 hours of PCV and PSV. After this period, animals were euth...

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Veröffentlicht in:Acta cirúrgica brasileira 2012-02, Vol.27 (2), p.109-116
Hauptverfasser: André de Sá Braga Oliveira, Lívia Bandeira Costa, Thiago de Oliveira Assis, Diógenes Luís da Mota, Eduardo Ériko Tenório de França, José Cândido de Araújo Filho, Silvania Tavares Paz Rosas, Paloma Lys de Medeiros
Format: Artikel
Sprache:eng
Schlagworte:
Anatomia & Histologia
Anatomy & Histology
Diafragma
Diaphragm
Ratos Wistar
Rats, Wistar
Tracheostomy
Traqueostomia
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Zusammenfassung:PURPOSE: The objective of this study was to analyze the effects of Pressure Controlled Ventilation mode (PCV-C) and PSV mode in diaphragm muscle of rats. METHODS: Wistar rats (n=18) were randomly assigned to the control group or to receive 6 hours of PCV and PSV. After this period, animals were euthanized and their diaphragms were excised, frozen in liquid nitrogen and stored in at -80º C for further histomorphometric analysis. RESULTS: Results showed a 15% decrease in cross-sectional area of muscle fibers on the PCV-C group when compared to the control group (p
ISSN:0102-8650
1678-2674
DOI:10.1590/S0102-86502012000200003