Global Picture of Genetic Relatedness and the Evolution of Humankind

We performed an exhaustive pairwise comparison of whole-genome sequences of 3120 individuals, representing 232 populations from all continents and seven prehistoric people including archaic and modern humans. In order to reveal an intricate picture of worldwide human genetic relatedness, 65 million...

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Veröffentlicht in:	Biology (Basel, Switzerland) Switzerland), 2020-11, Vol.9 (11), p.392
Hauptverfasser:	Khvorykh, Gennady V., Mulyar, Oleh A., Fedorova, Larisa, Khrunin, Andrey V., Limborska, Svetlana A., Fedorov, Alexei
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthropological research computational biology genealogy Genetic research genetic variation genomics Human evolution inheritance polymorphism Single nucleotide polymorphisms
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Zusammenfassung:	We performed an exhaustive pairwise comparison of whole-genome sequences of 3120 individuals, representing 232 populations from all continents and seven prehistoric people including archaic and modern humans. In order to reveal an intricate picture of worldwide human genetic relatedness, 65 million very rare single nucleotide polymorphic (SNP) alleles have been bioinformatically processed. The number and size of shared identical-by-descent (IBD) genomic fragments for every pair of 3127 individuals have been revealed. Over 17 million shared IBD fragments have been described. Our approach allowed detection of very short IBD fragments (
ISSN:	2079-7737 2079-7737
DOI:	10.3390/biology9110392