Analyses of nicotine metabolism biomarker genetics stratified by sex in African and European Americans

Analyses of nicotine metabolism biomarker genetics stratified by sex in African and European Americans

Nicotine is inactivated by the polymorphic CYP2A6 enzyme to cotinine and then to 3′hydroxycotinine. The Nicotine Metabolite Ratio (NMR; 3′hydroxycotinine/cotinine) is a heritable nicotine metabolism biomarker, varies with sex and ancestry, and influences smoking cessation and disease risk. We conduc...

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Veröffentlicht in:Scientific reports 2021-10, Vol.11 (1), p.19572-12, Article 19572
Hauptverfasser: Chenoweth, Meghan J., Cox, Lisa Sanderson, Nollen, Nikki L., Ahluwalia, Jasjit S., Benowitz, Neal L., Lerman, Caryn, Knight, Jo, Tyndale, Rachel F.
Format: Artikel
Sprache:eng
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Alleles
Biomarkers
Black or African American - genetics
Chromosome 12
Chromosome 19
Chromosome Mapping
Chromosomes
Cigarette smoking
Cotinine
Drug addiction
Female
Females
Genetic Markers
Genetics
Genome-Wide Association Study
Genomes
Genotype
Health risks
Humanities and Social Sciences
Humans
Male
Males
Metabolism
Metabolites
multidisciplinary
Nicotine
Nicotine - metabolism
Phenotype
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Quantitative Trait, Heritable
Science
Science (multidisciplinary)
Sex
Sex Factors
Smoking
Smoking cessation
White People - genetics
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Beschreibung
Zusammenfassung:Nicotine is inactivated by the polymorphic CYP2A6 enzyme to cotinine and then to 3′hydroxycotinine. The Nicotine Metabolite Ratio (NMR; 3′hydroxycotinine/cotinine) is a heritable nicotine metabolism biomarker, varies with sex and ancestry, and influences smoking cessation and disease risk. We conducted sex-stratified genome-wide association studies of the NMR in European American (EA) and African American (AA) smokers (NCT01314001, NCT00666978). In EA females (n = 389) and males (n = 541), one significant (P 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-98883-z