The 50th anniversary of the Italian League Against Epilepsy (Lega Italiana Contro l’Epilessia)

•We describe the 50-year history of the Italian League Against Epilepsy (LICE).•LICE promotes high-quality epilepsy care, education and research into epilepsy.•LICE maintains close relations with ILAE and other professional societies. This article was prepared to outline the article collection submitted on behalf of Lega Italiana Contro l’Epilessia, or LICE, for the 50th anniversary of the founding of the ILAE Italian Chapter, and provides a brief summary of the history, with its landmark achievements and challenges. LICE is a multidisciplinary, inclusive, educational, informative and multifaceted organization. Initially in 1955 and then formally in 1972, LICE was born in Milano, with the mission to devote itself to people suffering with epilepsy and by promoting appropriate treatment and care, integration into society, to promote and pursue all kinds of activities designed to achieve those aims. The LICE is currently composed of more than 1000 members including neurologists, pediatric neurologists, neurosurgeons, neurophysiologists, and neuropsychologists who function throughout Italy dealing mainly or exclusively with the diagnosis and treatment of people with epilepsy.