A Case of mistaken identity: Rhabdomyosarcoma development from endothelial progenitor cells

A Case of mistaken identity: Rhabdomyosarcoma development from endothelial progenitor cells

Rhabdomyosarcoma (RMS) histologically resembles developing skeletal muscle and is thought to solely originate from a differentiation block in muscle progenitors. We demonstrate that RMS can arise from endothelial progenitor cells following reprogramming and myogenic transdifferentiation. These resul...

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Veröffentlicht in:Molecular & cellular oncology 2018-07, Vol.5 (4), p.e1448246-e1448246
Hauptverfasser: Drummond, Catherine J., Hatley, Mark E.
Format: Artikel
Sprache:eng
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cell of origin
endothelial
hedgehog
muscle
pediatric cancer
reprogramming
rhabdomyosarcoma
sarcoma
skeletal muscle
transdifferentiation
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Zusammenfassung:Rhabdomyosarcoma (RMS) histologically resembles developing skeletal muscle and is thought to solely originate from a differentiation block in muscle progenitors. We demonstrate that RMS can arise from endothelial progenitor cells following reprogramming and myogenic transdifferentiation. These results highlight how tumors with identical morphological features can arise from different cell types and offer insight into RMS formation in non-myogenic tissue.
ISSN:2372-3556
2372-3556
DOI:10.1080/23723556.2018.1448246