Age, sex, and nutritional status modify the CD4+ T-cell recovery rate in HIV–tuberculosis co-infected patients on combination antiretroviral therapy

Age, sex, and nutritional status modify the CD4+ T-cell recovery rate in HIV–tuberculosis co-infected patients on combination antiretroviral therapy

Highlights • Age was examined in relation to CD4+ T-cell rise in HIV–tuberculosis (TB)-co-infected adults during combined antiretroviral therapy (cART). • Given cART, the age-related CD4+ T-cell recovery rate depended on sex and nutritional status. • Young age predicted CD4+ T-cell rise among women...

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Veröffentlicht in:International journal of infectious diseases 2015-06, Vol.35 (C), p.73-79
Hauptverfasser: Ezeamama, Amara E, Mupere, Ezekiel, Oloya, James, Martinez, Leonardo, Kakaire, Robert, Yin, Xiaoping, Sekandi, Juliet N, Whalen, Christopher C
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Age Factors
Aging
Body Mass Index
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes
Coinfection - immunology
Drug Therapy, Combination
Female
HAART
HIV
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - immunology
Humans
Immune-competence
Infectious Disease
Longitudinal Studies
Male
Middle Aged
Nutritional Status
Pulmonary/Respiratory
Sex Factors
Tuberculosis, Pulmonary - complications
Uganda
Young Adult
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Zusammenfassung:Highlights • Age was examined in relation to CD4+ T-cell rise in HIV–tuberculosis (TB)-co-infected adults during combined antiretroviral therapy (cART). • Given cART, the age-related CD4+ T-cell recovery rate depended on sex and nutritional status. • Young age predicted CD4+ T-cell rise among women and normally nourished patients. • Optimal nutrition in TB–HIV-co-infected patients may enhance CD4+ T-cell recovery given cART.
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2015.04.008