Cardioprotective effect of epigallocatechin gallate in myocardial ischemia/reperfusion injury and myocardial infarction: a meta-analysis in preclinical animal studies

This meta-analysis aims to determine the efficacy of Epigallocatechin gallate (EGCG) in the treatment of myocardial ischemia–reperfusion injury (MIRI) and summarize the mechanisms involved. Literature from six databases including Web of Science, PubMed, Embase, China National Knowledge Infrastructur...

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Veröffentlicht in:	Scientific reports 2023-08, Vol.13 (1), p.14050-14050, Article 14050
Hauptverfasser:	Wei, Xin-Yu, Zeng, Yi-Fan, Guo, Qi-Hao, Liu, Ji-Jia, Yin, Ni, Liu, Yan, Zeng, Wen-Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	692/308/2778 692/4019/592/75/2/1674 Angioplasty Animal models Apoptosis Cardiac function Confidence intervals Coronary vessels Enzymes Epigallocatechin gallate Heart attacks Hospitals Humanities and Social Sciences Ischemia Kinases Meta-analysis Mitochondrial DNA multidisciplinary Myocardial infarction Myocardial ischemia Oxidative stress Pharmacy Reperfusion Science Science (multidisciplinary) Veins & arteries
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Beschreibung
Zusammenfassung:	This meta-analysis aims to determine the efficacy of Epigallocatechin gallate (EGCG) in the treatment of myocardial ischemia–reperfusion injury (MIRI) and summarize the mechanisms involved. Literature from six databases including Web of Science, PubMed, Embase, China National Knowledge Infrastructure (CNKI), Wan-Fang database, and VIP database (VIP) were systematically searched. All the analysis were conducted by R. Twenty-five eligible studies involving 443 animals were included in this meta-analysis. The results indicated that compared to controls, EGCG exerts a cardioprotective effect by reducing myocardial infarct size (SMD = −4.06; 95% CI: −5.17, −2.94; P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-023-41275-2