Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer

Small cell lung cancer (SCLC) has a 5-year survival rate of

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Bibliographische Detailangaben
Veröffentlicht in:	Nature communications 2021-11, Vol.12 (1), p.6652-6652, Article 6652
Hauptverfasser:	Schenk, Maximilian W., Humphrey, Sam, Hossain, A. S. Md Mukarram, Revill, Mitchell, Pearsall, Sarah, Lallo, Alice, Brown, Stewart, Bratt, Samuel, Galvin, Melanie, Descamps, Tine, Zhou, Cong, Pearce, Simon P., Priest, Lynsey, Greenhalgh, Michelle, Chaturvedi, Anshuman, Kerr, Alastair, Blackhall, Fiona, Dive, Caroline, Frese, Kristopher K.
Format:	Artikel
Sprache:	eng
Schlagworte:	45/15 45/22 45/23 45/77 45/90 45/91 692/4028 692/53 82/80 Animals Cell culture Chemoresistance Chemotherapy Cyclic GMP-Dependent Protein Kinases - metabolism Disease Models, Animal Disease Progression Drug resistance Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Enzyme Inhibitors - therapeutic use Etoposide Etoposide - therapeutic use Gene Expression Regulation, Neoplastic Guanylate cyclase Humanities and Social Sciences Humans Kinases Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Mice multidisciplinary Neoplastic Cells, Circulating - metabolism Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type II - antagonists & inhibitors Nitric-oxide synthase Patients Platinum Pretreatment Protein kinase Protein kinase G Receptors, Notch - metabolism Science Science (multidisciplinary) Signal transduction Signal Transduction - genetics Signaling Small cell lung carcinoma Small Cell Lung Carcinoma - drug therapy Small Cell Lung Carcinoma - metabolism Small Cell Lung Carcinoma - pathology Soluble Guanylyl Cyclase - genetics Soluble Guanylyl Cyclase - metabolism Survival Tumors
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Beschreibung
Zusammenfassung:	Small cell lung cancer (SCLC) has a 5-year survival rate of
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-021-26823-6