Low expression of DUSP4 expression predicts unfavorable prognosis in gallbladder adenocarcinoma

Low expression of DUSP4 expression predicts unfavorable prognosis in gallbladder adenocarcinoma

Background: Dual specificity phosphatase 4 (DUSP4), which regulates the mitogen activated protein kinases, has emerged as a tumor suppressor gene in several human malignancies. Aims and Objectives: In this study, we investigated the clinicopathologic significance and the prognostic role of DUSP4 in...

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Veröffentlicht in:Indian journal of pathology & microbiology 2022-10, Vol.65 (4), p.809-813
Hauptverfasser: Jee, Seungyun, Sim, Jongmin, Bang, Seongsik, Park, Hosub, Myung, Jaekyung, Paik, Seung, Choi, Dongho, Kim, Yeseul, Kim, Hyunsung
Format: Artikel
Sprache:eng
Schlagworte:
Adenocarcinoma
Analysis
Cancer
DNA microarrays
dual-specificity phosphatase 4
Gallbladder
gallbladder adenocarcinoma
Gallbladder cancer
immunohistochemistry
Kinases
Malignancy
Medical prognosis
Mitogens
Phosphatases
Prognosis
Protein kinase
Rank tests
Survival
Tumor suppressor genes
Tumors
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Zusammenfassung:Background: Dual specificity phosphatase 4 (DUSP4), which regulates the mitogen activated protein kinases, has emerged as a tumor suppressor gene in several human malignancies. Aims and Objectives: In this study, we investigated the clinicopathologic significance and the prognostic role of DUSP4 in gallbladder adenocarcinoma. Materials and methods: DUSP4 expression was evaluated immunohistochemically in tissue microarray from 110 gallbladder adenocarcinoma samples and scored by H score system. The cut off (H score
ISSN:0377-4929
0974-5130
DOI:10.4103/ijpm.ijpm_352_21