Early prolonged prone position in noninvasively ventilated patients with SARS-CoV-2-related moderate-to-severe hypoxemic respiratory failure: clinical outcomes and mechanisms for treatment response in the PRO-NIV study

Whether prone position (PP) improves clinical outcomes in COVID-19 pneumonia treated with noninvasive ventilation (NIV) is unknown. We evaluated the effect of early PP on 28-day NIV failure, intubation and death in noninvasively ventilated patients with moderate-to-severe acute hypoxemic respiratory...

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Veröffentlicht in:	Critical care (London, England) England), 2022-04, Vol.26 (1), p.118-118, Article 118
Hauptverfasser:	Musso, Giovanni, Taliano, Claudio, Molinaro, Federica, Fonti, Caterina, Veliaj, Deliana, Torti, Davide, Paschetta, Elena, Castagna, Elisabetta, Carbone, Giorgio, Laudari, Luigi, Aseglio, Claudio, Zocca, Edoardo, Chioni, Sonia, Giannone, Laura Ceretto, Arabia, Federica, Deiana, Cecilia, Benato, Francesca Maria, Druetta, Marta, Campagnola, Giorgio, Borsari, Margherita, Mucci, Martina, Rubatto, Tiziana, Peyronel, Mara, Tirabassi, Gloria
Format:	Artikel
Sprache:	eng
Schlagworte:	Artificial respiration Care and treatment Complications and side effects Coronaviruses Corrected minute ventilation COVID-19 COVID-19 - complications COVID-19 - therapy Critical care Dead space Humans Hypoxemia Lung ultrasound Mortality Noninvasive ventilation Noninvasive Ventilation - adverse effects Patients Positioning Prone Position Prospective Studies Respiration, Artificial Respiratory Distress Syndrome Respiratory failure Respiratory insufficiency Respiratory Insufficiency - etiology Respiratory Insufficiency - therapy SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Ventilators Ventilatory ratio
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Zusammenfassung:	Whether prone position (PP) improves clinical outcomes in COVID-19 pneumonia treated with noninvasive ventilation (NIV) is unknown. We evaluated the effect of early PP on 28-day NIV failure, intubation and death in noninvasively ventilated patients with moderate-to-severe acute hypoxemic respiratory failure due to COVID-19 pneumonia and explored physiological mechanisms underlying treatment response. In this controlled non-randomized trial, 81 consecutive prospectively enrolled patients with COVID-19 pneumonia and moderate-to-severe (paO2/FiO2 ratio
ISSN:	1364-8535 1466-609X 1364-8535 1366-609X
DOI:	10.1186/s13054-022-03937-x