Increases in Serum Nitrite and Nitrate of a Few-Fold Adversely Affect the Outcome of Pregnancy in Rats

The objective of this study was to evaluate serum nitrite and nitrate (nitrite/nitrate) concentrations that affect adversely pregnancy outcome. Pregnant rats, from day 2 to day 8 of pregnancy, were daily given subcutaneously several doses (5, 10, and 30 mg/rat) of diethylenetriamine-nitric oxide (DE...

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Veröffentlicht in:	Journal of Pharmacological Sciences 2004, Vol.95(2), pp.228-233
Hauptverfasser:	Inoue, Tsuneo, Kaibara, Muneshige, Sakurai-Yamashita, Yasuko, Kawano, Masahiro, Ishimaru, Tadayuki, Taniyama, Kohtaro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cell Proliferation - drug effects Chorionic Gonadotropin - metabolism Culture Media diethylenetriamine-NO Female Fetal Weight - drug effects Half-Life Hormones - metabolism HPLC Humans Nitrates - blood nitric oxide (NO) Nitric Oxide - metabolism Nitric Oxide Donors - pharmacology Nitrites - blood Placenta - drug effects Placentation Polyamines - pharmacology Pregnancy Pregnancy Outcome Progesterone - metabolism Rats Rats, Wistar Trophoblasts - drug effects
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Zusammenfassung:	The objective of this study was to evaluate serum nitrite and nitrate (nitrite/nitrate) concentrations that affect adversely pregnancy outcome. Pregnant rats, from day 2 to day 8 of pregnancy, were daily given subcutaneously several doses (5, 10, and 30 mg/rat) of diethylenetriamine-nitric oxide (DETA/NO). Serum nitrite/nitrate concentrations were measured using an HPLC system. Serum nitrite/nitrate concentrations increased dose-dependently with DETA/NO. Effects of DETA/NO on pregnancy outcome were assessed on day 14 of pregnancy. In rats given 5 mg DETA/NO, there was a significant increase in serum nitrite/nitrate concentrations (49.2 vs 24.6 μmol/l, P
ISSN:	1347-8613 1347-8648
DOI:	10.1254/jphs.fp0040125