Risk of chronic liver disease in post-menopausal women due to body mass index, alcohol and their interaction: a prospective nested cohort study within the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)

Risk of chronic liver disease in post-menopausal women due to body mass index, alcohol and their interaction: a prospective nested cohort study within the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)

We investigated the risk of chronic liver disease (CLD) due to alcohol consumption and body mass index (BMI) and the effects of their interaction in a prospective cohort study of women recruited to the UKCTOCS trial. 95,126 post-menopausal women without documented CLD were stratified into 12 groups...

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Veröffentlicht in:BMC public health 2017-06, Vol.17 (1), p.603-9, Article 603
Hauptverfasser: Trembling, Paul M, Apostolidou, Sophia, Gentry-Maharaj, Aleksandra, Parkes, Julie, Ryan, Andy, Tanwar, Sudeep, Burnell, Matthew, Jacobs, Ian, Menon, Usha, Rosenberg, William M
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Alcohol
Alcohol Drinking - adverse effects
Alcohol use
Alcohols
Analysis
Body Mass Index
Body size
Body weight
Cancer screening
Chronic Disease
Chronic liver disease
Cirrhosis
Cohort analysis
Drinking
Drinking (Alcoholic beverages)
Drinking behavior
Ethanol - adverse effects
Female
Health aspects
Humans
International standards
Liver
Liver cirrhosis
Liver diseases
Liver Diseases - etiology
Menopause
Middle Aged
Mortality
Obesity
Obesity - complications
Ovarian cancer
Ovarian Neoplasms - diagnosis
Overweight
Overweight - complications
Post-menopause
Postmenopause
Proportional Hazards Models
Prospective Studies
Public health
Risk analysis
Risk Factors
Studies
United Kingdom
Women's health
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Beschreibung
Zusammenfassung:We investigated the risk of chronic liver disease (CLD) due to alcohol consumption and body mass index (BMI) and the effects of their interaction in a prospective cohort study of women recruited to the UKCTOCS trial. 95,126 post-menopausal women without documented CLD were stratified into 12 groups defined by combinations of BMI (normal, overweight, obese) and alcohol consumption (none,
ISSN:1471-2458
1471-2458
DOI:10.1186/s12889-017-4518-y