Serum 25 Hydroxy Vitamin D3 Levels in Type 2 Diabetic Patients

Aim:Accumulating knowledge suggests that low 25-hydroxyvitamin D3 concentrations may be inversely related to diabetes mellitus and insulin resistance. We planned to investigate the association of 25-hydroxyvitamin D3 levels with some antropometric and metabolic data in type 2 diabetic patients. Methods: In our study including 101 patients with type 2 diabetes mellitus and 60 healthy controls, after making comparisons of 25-hydroxyvitamin D3 levels and other parameters of two groups, we made correlation analysis in our diabetic patients. Later, we grouped our patients according to their 25-hydroxyvitamin D3 levels and made comparisons. Results: We found significantly lower 25-hydroxyvitamin D3 levels in type 2 diabetic patients than in controls. In correlation analysis, 25-hydroxyvitamin D3 levels were found to be negatively correlated with insulin homeostasis model assessment index. When we grouped our diabetic patients according to 25-hydroxyvitamin D3 levels, no difference was demonstrated in any parameters. Conclusion: This study suggests that 25-hydroxyvitamin D3 levels are significantly low in type 2 diabetes mellitus. In patients with type 2 diabetes, once vitamin D deficiency exists, metabolic parameters do not worsen according to decreasing vitamin D levels. Since hypovitaminosis D also exists in non-diabetics, we recommend vitamin D supplementation in our population . (The Medical Bulletin of Haseki 2013; 51: 89-94)