Derecruitment volume assessment derived from pressure–impedance curves with electrical impedance tomography in experimental acute lung injury

Objective To investigate the accuracy of derecruitment volume (VDER) assessed by pressure–impedance (P-I) curves derived from electrical impedance tomography (EIT). Methods Six pigs with acute lung injury received decremental positive end-expiratory pressure (PEEP) from 15 to 0 in steps of 5 cmH2O. At the end of each PEEP level, the pressure–volume (P-V) curves were plotted using the low constant flow method and release maneuvers to calculate the VDER between the PEEP of setting levels and 0 cmH2O (VDER-PV). The VDER derived from P-I curves that were recorded simultaneously using EIT was the difference in impedance at the same pressure multiplied by the ratio of tidal volume and corresponding tidal impedance (VDER-PI). The regional P-I curves obtained by EIT were used to estimate VDER in the dependent and nondependent lung. Results The global lung VDER-PV and VDER-PI showed close correlations (r = 0.948, P