Coinfection by Hepatitis C Is Strongly Associated with Abnormal CD4/CD8 Ratio in HIV Patients under Stable ART in Salvador, Brazil

Coinfection by Hepatitis C Is Strongly Associated with Abnormal CD4/CD8 Ratio in HIV Patients under Stable ART in Salvador, Brazil

Proper immune restoration (CD4 count >500 and normal CD4/8 ratio) is reached only by a fraction of HIV patients, despite stable viral suppression. Methods. We present a case-control study to compare HIV patients with viral suppression >1 year, according to immune restoration pattern: adequate...

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Veröffentlicht in:Journal of Immunology Research 2015-01, Vol.2015 (2015), p.1-6
Hauptverfasser: Brites-Alves, Clara, Brites, Carlos, Netto, Eduardo Martins
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Antiretroviral Therapy, Highly Active
Brazil - epidemiology
Case-Control Studies
CD4 Lymphocyte Count
CD4-CD8 Ratio
Coinfection
Complications and side effects
Diseases
Drug therapy
Female
Genetic aspects
Hepatitis C
Hepatitis C - epidemiology
Hepatitis C - immunology
Hepatitis C virus
HIV Infections - drug therapy
HIV Infections - epidemiology
HIV Infections - immunology
HIV Infections - virology
HIV patients
Human immunodeficiency virus
Humans
Immunology
Male
Middle Aged
Physiological aspects
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Zusammenfassung:Proper immune restoration (CD4 count >500 and normal CD4/8 ratio) is reached only by a fraction of HIV patients, despite stable viral suppression. Methods. We present a case-control study to compare HIV patients with viral suppression >1 year, according to immune restoration pattern: adequate response (AR) defined by CD4 > 500 cells/mm3 and CD4/8 ratio >1; partial response (PR = patients with CD4 > 500, but CD4/8 ratio
ISSN:2314-8861
2314-7156
DOI:10.1155/2015/174215