Serum biomarkers and anti-flavivirus antibodies at presentation as indicators of severe dengue

Dengue is the most common vector-borne viral disease worldwide. Most cases are mild, but some evolve into severe dengue (SD), with high lethality. Therefore, it is important to identify biomarkers of severe disease to improve outcomes and judiciously utilize resources. One hundred forty-five confirm...

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Veröffentlicht in:	PLoS neglected tropical diseases 2023-02, Vol.17 (2), p.e0010750-e0010750
Hauptverfasser:	Bernal, Cynthia, Ping, Sara, Rojas, Alejandra, Caballero, Oliver, Stittleburg, Victoria, de Guillén, Yvalena, Langjahr, Patricia, Pinsky, Benjamin A, Von-Horoch, Marta, Luraschi, Patricia, Cabral, Sandra, Sánchez, María Cecilia, Torres, Aurelia, Cardozo, Fátima, Waggoner, Jesse J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies Antibodies, Viral Antigens Biological markers Biology and life sciences Biomarkers Care and treatment Chymase Chymases Clinical outcomes Comorbidity Confidence intervals Dengue Dengue fever Dengue hemorrhagic fever Development and progression Enrollments Enzyme-Linked Immunosorbent Assay Epidemics Evaluation Female Flavivirus Gender Health aspects Human diseases Humans Identification and classification Illnesses Immunoglobulin G Immunoglobulin M Laboratories Lethality Lipopolysaccharides Lymphocytes Male Medicine and Health Sciences Multiplexing Prognosis Regression models Research and Analysis Methods Serology Serum Severe Dengue - diagnosis Statistical analysis Tropical diseases Vector-borne diseases Viral diseases Viroses Viruses Zika virus
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Beschreibung
Zusammenfassung:	Dengue is the most common vector-borne viral disease worldwide. Most cases are mild, but some evolve into severe dengue (SD), with high lethality. Therefore, it is important to identify biomarkers of severe disease to improve outcomes and judiciously utilize resources. One hundred forty-five confirmed dengue cases (median age, 42; range
ISSN:	1935-2735 1935-2727 1935-2735
DOI:	10.1371/journal.pntd.0010750