Mass Spectrometry Strategies for O -Glycoproteomics

Mass Spectrometry Strategies for O -Glycoproteomics

Glycoproteomics has accelerated in recent decades owing to numerous innovations in the analytical workflow. In particular, new mass spectrometry strategies have contributed to inroads in -glycoproteomics, a field that lags behind -glycoproteomics due to several unique challenges associated with the...

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Veröffentlicht in:Cells (Basel, Switzerland) Switzerland), 2024-02, Vol.13 (5), p.394
Hauptverfasser: Helms, Amanda, Brodbelt, Jennifer S
Format: Artikel
Sprache:eng
Schlagworte:
analytical workflow
Biomarkers
Data processing
Disease
enrichment
Enzymes
glycans
glycoprotease
Glycoproteins
glycoproteomics
Glycosylation
Localization
Mass spectrometry
Mass spectroscopy
Metastasis
Peptides
Protein folding
Proteomics
Review
Scientific imaging
tandem mass spectrometry
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Beschreibung
Zusammenfassung:Glycoproteomics has accelerated in recent decades owing to numerous innovations in the analytical workflow. In particular, new mass spectrometry strategies have contributed to inroads in -glycoproteomics, a field that lags behind -glycoproteomics due to several unique challenges associated with the complexity of -glycosylation. This review will focus on progress in sample preparation, enrichment strategies, and MS/MS techniques for the identification and characterization of -glycoproteins.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells13050394