Role of hyaluronic acid and laminin as serum markers for predicting significant fibrosis in patients with chronic hepatitis B

The aim of this study was to evaluate the diagnostic performance of serum HA and LN as serum markers for predicting significant fibrosis in CHB patients. Serum HA and LN levels of 87 patients with chronic hepatitis B and 19 blood donors were assayed by RIA. Liver fibrosis stages were determined acco...

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Veröffentlicht in:	The Brazilian journal of infectious diseases 2012-01, Vol.16 (1), p.9-14
Hauptverfasser:	Li, Feng, Zhu, Chang-Lai, Zhang, Hong, Huang, Hua, Wei, Qun, Zhu, Xiang, Cheng, Xiao-Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomarkers - blood Case-Control Studies China Cirrhosis Development and progression Diagnosis Female Fibrosis Hepatitis B Hepatitis B, chronic Hepatitis B, Chronic - blood Hepatitis B, Chronic - complications Humans Hyaluronic acid Hyaluronic Acid - blood Laminin Laminin - blood Liver Liver Cirrhosis - blood Liver Cirrhosis - diagnosis Liver Cirrhosis - etiology Male Medical research Medicine, Experimental Predictive Value of Tests ROC curve Sensitivity and Specificity
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Zusammenfassung:	The aim of this study was to evaluate the diagnostic performance of serum HA and LN as serum markers for predicting significant fibrosis in CHB patients. Serum HA and LN levels of 87 patients with chronic hepatitis B and 19 blood donors were assayed by RIA. Liver fibrosis stages were determined according to the Metavir scoring-system. The diagnostic performances of all indexes were evaluated by the receiver operating characteristic (ROC) curves. Serum HA and LN concentrations increased significantly with the stage of hepatic fibrosis, which showed positive correlation with the stages of liver fibrosis (HA: r =0.875, p
ISSN:	1413-8670 1678-4391
DOI:	10.1016/S1413-8670(12)70267-2