Age, Sex, and Valve Phenotype Differences in Fibro-Calcific Remodeling of Calcified Aortic Valve

Background In calcific aortic valve disease on tricuspid aortic valves (TAVs), men have higher aortic valve calcification and less fibrosis than women. However, little is known in bicuspid aortic valves (BAV). We thus aimed to investigate the impact of age, sex, and valve phenotype (TAVs versus BAVs...

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Veröffentlicht in:	Journal of the American Heart Association 2020-05, Vol.9 (10), p.e015610-e015610
Hauptverfasser:	Voisine, Martine, Hervault, Maxime, Shen, Mylène, Boilard, Anne-Julie, Filion, Benoît, Rosa, Mickael, Bossé, Yohan, Mathieu, Patrick, Côté, Nancy, Clavel, Marie-Annick
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aged Aged, 80 and over aortic stenosis Aortic Valve - abnormalities Aortic Valve - chemistry Aortic Valve - diagnostic imaging Aortic Valve - metabolism Aortic Valve - pathology Aortic Valve - physiopathology Aortic Valve Stenosis - diagnostic imaging Aortic Valve Stenosis - metabolism Aortic Valve Stenosis - pathology Aortic Valve Stenosis - physiopathology bicuspid Bicuspid Aortic Valve Disease - diagnostic imaging Bicuspid Aortic Valve Disease - metabolism Bicuspid Aortic Valve Disease - pathology Bicuspid Aortic Valve Disease - physiopathology calcification Calcinosis - diagnostic imaging Calcinosis - metabolism Calcinosis - pathology Calcinosis - physiopathology Collagen - analysis Female Fibrosis Health Status Disparities Hemodynamics Humans Male Middle Aged Original Research Phenotype Risk Assessment Risk Factors sex Sex Factors tricuspid
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Zusammenfassung:	Background In calcific aortic valve disease on tricuspid aortic valves (TAVs), men have higher aortic valve calcification and less fibrosis than women. However, little is known in bicuspid aortic valves (BAV). We thus aimed to investigate the impact of age, sex, and valve phenotype (TAVs versus BAVs) on fibro-calcific remodeling in calcific aortic valve disease. Methods and Results We included 2 cohorts: 411 patients who underwent multidetector computed tomography (37% women) for aortic valve calcification density assessment and 138 explanted aortic valves (histological cohort; 50% women). The cohorts were divided in younger (
ISSN:	2047-9980 2047-9980
DOI:	10.1161/JAHA.119.015610