A case of nonislet cell tumor hypoglycemia associated with malignant mesothelioma requiring a multifaceted approach for optimal glycemic control

Nonislet tumor hypoglycemia (NICTH) is a rare paraneoplastic syndrome characterized by refractory hypoglycemia, which often requires multifaceted therapy. We reported a case of a patient with pleural malignant mesothelioma and developed NICTH, for which chemotherapy, glucocorticoids, and nutrition were given to achieve optimal glycemic control. In patients with tumors and hypoglycemia without clear etiology, nonislet cell tumor hypoglycemia (NICTH), which can cause severe refractory hypoglycemia, should be considered. If tumor resection is not feasible, a multifaceted therapeutic approach that includes anticancer drugs, corticosteroids, and nutrition may be required for the management of NICTH.