Association of remnant cholesterol and newly diagnosed early‐onset type 2 diabetes mellitus in Chinese population: A retrospective cross‐sectional study

Background With the increasing incidence of diabetes worldwide, patients diagnosed with diabetes has been getting younger. Previous studies have shown that high remnant cholesterol (RC) level leads to an increased risk of cardiovascular disease events. However, the relationship between RC levels and newly diagnosed early‐onset type 2 diabetes mellitus (T2DM) is unknown. This study aimed to explore the association between RC and newly diagnosed early‐onset T2DM. Methods A total of 606 patients newly diagnosed with early‐onset T2DM and 619 gender‐matched subjects with normal blood glucose levels were retrospectively enrolled in this study. All T2DM patients showed onset age of 18–40 years. Binary logistic regression analysis was performed to analyze independent risk factors and receiver operating characteristic (ROC) analysis was used to explore the predictive value of RC and other unconventional lipids. Moreover, the correlation between RC and insulin resistance in patients with newly diagnosed early‐onset T2DM was also examined with binary logistic regression analysis and Spearman correlation analysis. Results Increased RC level was an independent risk factor for early‐onset T2DM (p 0.32 mmol/L showed an increased risk of developing T2DM. Highlights This study was the first to explore the association between remnant cholesterol (RC) levels and newly diagnosed early‐onset type 2 diabetes mellitus (T2DM). We found that the risk of T2DM was increased when people aged 18–40 years had