The Omnipresence of DYRK1A in Human Diseases

The increasing population will challenge healthcare, particularly because the worldwide population has never been older. Therapeutic solutions to age-related disease will be increasingly critical. Kinases are key regulators of human health and represent promising therapeutic targets for novel drug c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of molecular sciences 2022-08, Vol.23 (16), p.9355
Hauptverfasser:	Deboever, Estelle, Fistrovich, Alessandra, Hulme, Christopher, Dunckley, Travis
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease cancers Cell cycle Cell division Cyclin-dependent kinases diabetes Disease Down syndrome Drug development Dyrk Kinases DYRK1A Gene expression Genomes Health care Humans Intellectual disabilities Kinases Localization neurodegenerative diseases Phosphorylation protein kinase Protein Serine-Threonine Kinases - genetics Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Proteins Review Therapeutic targets Tyrosine viral infections
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The increasing population will challenge healthcare, particularly because the worldwide population has never been older. Therapeutic solutions to age-related disease will be increasingly critical. Kinases are key regulators of human health and represent promising therapeutic targets for novel drug candidates. The dual-specificity tyrosine-regulated kinase (DYRKs) family is of particular interest and, among them, DYRK1A has been implicated ubiquitously in varied human diseases. Herein, we focus on the characteristics of DYRK1A, its regulation and functional role in different human diseases, which leads us to an overview of future research on this protein of promising therapeutic potential.
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms23169355