“Interferon magic” in ocular surface squamous neoplasia

An elderly patient with limbal growth in the left eye was diagnosed by impression cytology as ocular surface squamous neoplasia (OSSN) and subsequently treated with topical interferon α 2b (IFN-α 2b). Complete gross and histopathological resolution was seen by 3 months. Impression cytology and topical IFN-α 2b drops are simple, powerful, and affordable tools to manage OSSN. Flu-like syndrome in the first few days was the only adverse effect noted.