Critical finger ischemia and myocardial fibrosis development after sudden interruption of sildenafil treatment in a systemic sclerosis patient

Systemic sclerosis (SSc) is a connective tissue disease frequently associated with Raynaud's Phenomenon (RP). Among possible pharmacological treatments, phosphodiesterase 5 inhibitors are considered in cases of severe non -responsive RP. We present the case of a male SSc patient wh presented wi...

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Veröffentlicht in:	Reumatismo 2016-09, Vol.68 (2), p.109-111
Hauptverfasser:	Bruni, C, Bellando-Randone, S, Gargani, L, Picano, E, Pingitore, A, Matucci-Cerinic, M, Guiducci, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Antirheumatic Agents - adverse effects Antirheumatic Agents - therapeutic use cardiac magnetic resonance imaging Cardiomyopathies - etiology Cardiomyopathies - pathology critical ischemia Fingers - blood supply Humans Ischemia Male Middle Aged myocardial fibrosis Myocardium - pathology phosphodiesterase 5 inhibitors Raynaud Disease - complications Raynaud Disease - drug therapy Raynaud Disease - pathology Risk Factors Scleroderma Scleroderma, Systemic - complications Scleroderma, Systemic - drug therapy Scleroderma, Systemic - pathology Sildenafil Citrate - adverse effects Sildenafil Citrate - therapeutic use Substance Withdrawal Syndrome Systemic sclerosis Time Factors
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Zusammenfassung:	Systemic sclerosis (SSc) is a connective tissue disease frequently associated with Raynaud's Phenomenon (RP). Among possible pharmacological treatments, phosphodiesterase 5 inhibitors are considered in cases of severe non -responsive RP. We present the case of a male SSc patient wh presented with critical finger ischemia and concomitant appearance of myocardial fibrosis after sudden interruption of sildenafil treatment.
ISSN:	0048-7449 2240-2683
DOI:	10.4081/reumatismo.2016.889